Medusa's main use is instantly killing a potentially dangerous unit with its main ability, (with the exception of Enslaved Giants, Giants, other Medusas, Speartons in Shield Wall, Charrog, and Treature even then are severely damaged). It is reccommended to Petrify Spellcasters or tanks (if they have none).
Petrify works on Statues, making Medusa dangerous for sieging as well, six/seven petrify can destroy a statue.
It can also use Venom Flux as a deterrent to any attack, as it will poison units.
Venom Flux is usually used in order to give Medusa more space between enemies.
It is also effective at taking on weak ranged units (note that this spell can hit air units when cast). Although units can still get past, it can weaken mass rushes.